RT Journal Article
SR Electronic
T1 Liver enzymes: No trivial elevations, even if asymptomatic
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 612
OP 617
DO 10.3949/ccjm.85a.17103
VO 85
IS 8
A1 Brian Agganis
A1 David Lee
A1 Thomas Sepe
YR 2018
UL http://www.ccjm.org/content/85/8/612.abstract
AB Primary care physicians are at the forefront in screening for abnormal levels of liver enzymes and investigating the likely causes by obtaining a detailed history and physical examination, followed by appropriate laboratory and diagnostic workup. This review outlines common causes for the two main mechanisms of liver injury—cholestasis and hepatocellular insult—and explores the associated risk factors, methods of diagnosis, and management, with a focus on nonalcoholic fatty liver disease, one of the most often encountered causes of abnormal liver enzyme levels.