PT - JOURNAL ARTICLE AU - Sherif Beniameen Mossad TI - Influenza update 2018–2019: 100 years after the great pandemic AID - 10.3949/ccjm.85a.18095 DP - 2018 Nov 01 TA - Cleveland Clinic Journal of Medicine PG - 861--869 VI - 85 IP - 11 4099 - http://www.ccjm.org/content/85/11/861.short 4100 - http://www.ccjm.org/content/85/11/861.full SO - Cleve Clin J Med2018 Nov 01; 85 AB - Four influenza pandemics, starting with the historic 1918 pandemic, have killed thousands of people around the world. Vaccination, still the most important means of pre-venting influenza, is currently recommended yearly for all people age 6 months and older, with a goal of vaccinating 80% of all Americans and 90% of at-risk populations. Neuraminidase inhibitors are underused, and a new drug with a different mechanism of action, baloxavir marboxil, is expected to be approved soon in the United States.