PT - JOURNAL ARTICLE AU - Rodeman, Kathryn Bux AU - Hatipoglu, Betul TI - Beta-cell therapies for type 1 diabetes: Transplants and bionics AID - 10.3949/ccjm.85a.17088 DP - 2018 Dec 01 TA - Cleveland Clinic Journal of Medicine PG - 931--937 VI - 85 IP - 12 4099 - http://www.ccjm.org/content/85/12/931.short 4100 - http://www.ccjm.org/content/85/12/931.full SO - Cleve Clin J Med2018 Dec 01; 85 AB - Research continues toward the goal of treating type 1 diabetes by replacing insulin-producing beta cells. Ideally, such treatment would be safe and long-lasting and would eliminate the need for subcutaneous insulin replacement. This article reviews the current state of beta-cell replacement through transplant of the whole pancreas or of islet cells. It also looks at the “bionic” pancreas and other future challenges.