PT - JOURNAL ARTICLE AU - Guramrinder S. Thind AU - Mark Loehrke AU - Jeffrey L. Wilt TI - Acute cardiorenal syndrome: Mechanisms and clinical implications AID - 10.3949/ccjm.85a.17019 DP - 2018 Mar 01 TA - Cleveland Clinic Journal of Medicine PG - 231--239 VI - 85 IP - 3 4099 - http://www.ccjm.org/content/85/3/231.short 4100 - http://www.ccjm.org/content/85/3/231.full SO - Cleve Clin J Med2018 Mar 01; 85 AB - Cardiac and renal dysfunction often coexist, and one begets the other. The association is referred to as cardio-renal syndrome. One subtype, acute cardiorenal syndrome, is often described as a clinical scenario in which acute worsening of cardiac function leads to acute kidney injury. Though this definition covers the basic pathophysiologic framework, a robust clinical definition is still lacking. Acute cardiorenal syndrome is common and often leads to emergency room visits and hospitalization. Our understanding of the hemodynamic mechanisms of acute cardiorenal syndrome is advancing. Correction of hypervolemia is the mainstay of therapy.