RT Journal Article SR Electronic T1 Use and misuse of opioid agonists in opioid addiction JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 377 OP 384 DO 10.3949/ccjm.84a.16091 VO 84 IS 5 A1 Modesto-Lowe, Vania A1 Swiezbin, Katie A1 Chaplin, Margaret A1 Hoefer, Gabriela YR 2017 UL http://www.ccjm.org/content/84/5/377.abstract AB Although methadone (an opioid agonist) and buprenorphine (a partial opioid agonist) have evidence to support their use in treating opioid use disorder, they remain misunderstood and underutilized. In this article, we outline the risks and benefits of using these drugs as maintenance therapy in opioid-dependent patients.