RT Journal Article SR Electronic T1 Combined hormonal contraceptives and migraine: An update on the evidence JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 631 OP 638 DO 10.3949/ccjm.84a.16033 VO 84 IS 8 A1 Anne H. Calhoun A1 Pelin Batur YR 2017 UL http://www.ccjm.org/content/84/8/631.abstract AB Combined hormonal contraceptives are contraindicated in women who have migraine with aura, in whom these drugs can increase the risk of ischemic stroke. However, this contraindication is based on data from the 1960s and 1970s, when oral contraceptives contained much higher doses of estrogen. Stroke risk is not significantly increased with today’s preparations, many of which contain less than 30 μg of ethinyl estradiol. Further, in continuous regimens, ultra-low-dose formulations—those that contain less than 20 µg of ethinyl estradiol—may help prevent menstrual migraine and reduce the frequency of aura.