TY - JOUR T1 - Renal denervation: What happened, and why? JF - Cleveland Clinic Journal of Medicine JO - Cleve Clin J Med SP - 681 LP - 686 DO - 10.3949/ccjm.84a.14129 VL - 84 IS - 9 AU - Mehdi H. Shishehbor AU - Tarek A. Hammad AU - George Thomas Y1 - 2017/09/01 UR - http://www.ccjm.org/content/84/9/681.abstract N2 - Despite promising results in initial trials, renal denervation failed to achieve its efficacy end points as a treatment for resistant hypertension in the SYMPLICITY HTN-3 trial, the largest trial of this treatment to date (N Engl J Med 2014; 370:1393-1401). Is renal denervation dead, or will future trials and newer technology revive it? ER -