PT - JOURNAL ARTICLE AU - Shishehbor, Mehdi H. AU - Hammad, Tarek A. AU - Thomas, George TI - Renal denervation: What happened, and why? AID - 10.3949/ccjm.84a.14129 DP - 2017 Sep 01 TA - Cleveland Clinic Journal of Medicine PG - 681--686 VI - 84 IP - 9 4099 - http://www.ccjm.org/content/84/9/681.short 4100 - http://www.ccjm.org/content/84/9/681.full SO - Cleve Clin J Med2017 Sep 01; 84 AB - Despite promising results in initial trials, renal denervation failed to achieve its efficacy end points as a treatment for resistant hypertension in the SYMPLICITY HTN-3 trial, the largest trial of this treatment to date (N Engl J Med 2014; 370:1393-1401). Is renal denervation dead, or will future trials and newer technology revive it?