RT Journal Article SR Electronic T1 Renal denervation: What happened, and why? JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 681 OP 686 DO 10.3949/ccjm.84a.14129 VO 84 IS 9 A1 Mehdi H. Shishehbor A1 Tarek A. Hammad A1 George Thomas YR 2017 UL http://www.ccjm.org/content/84/9/681.abstract AB Despite promising results in initial trials, renal denervation failed to achieve its efficacy end points as a treatment for resistant hypertension in the SYMPLICITY HTN-3 trial, the largest trial of this treatment to date (N Engl J Med 2014; 370:1393-1401). Is renal denervation dead, or will future trials and newer technology revive it?