RT Journal Article SR Electronic T1 Approach to asymptomatic creatine kinase elevation JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 37 OP 42 DO 10.3949/ccjm.83a.14120 VO 83 IS 1 A1 Siamak Moghadam-Kia A1 Chester V. Oddis A1 Rohit Aggarwal YR 2016 UL http://www.ccjm.org/content/83/1/37.abstract AB How to manage a patient who has an elevated serum creatine kinase (CK) level but no or insignificant muscle-related signs and symptoms is a clinical conundrum. The authors provide a systematic approach, including repeat testing after a period of rest, defining higher thresholds over which pursuing a diagnosis is worthwhile, and evaluating for a variety of nonneuromuscular causes. They also outline a workup for neuromuscular causes.