PT  - JOURNAL ARTICLE
AU  - Sumita B. Khatri
AU  - Octavian C. Ioachimescu
TI  - The intersection of obstructive lung disease and sleep apnea
AID  - 10.3949/ccjm.83a.14104
DP  - 2016 Feb 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 127--140
VI  - 83
IP  - 2
4099  - http://www.ccjm.org/content/83/2/127.short
4100  - http://www.ccjm.org/content/83/2/127.full
SO  - Cleve Clin J Med2016 Feb 01; 83
AB  - Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) have synergistic detrimental effects. Their comorbid association leads to compromised gas exchange (hypoxia and hypercapnia) and higher rates of morbidity and death. As our understanding of the pathophysiologic processes of sleep evolves, the relation-ship between OSA and obstructive lung diseases such as COPD (“overlap syndrome”) or asthma (“alternative overlap syndrome”) has become more apparent. The pathophysiology of the combined conditions and optimal management are still being defined, but the effect on quality of life and morbidity underscore the importance of proper diagnosis and appropriately tailored management in these patients.