TY - JOUR T1 - The intersection of obstructive lung disease and sleep apnea JF - Cleveland Clinic Journal of Medicine JO - Cleve Clin J Med SP - 127 LP - 140 DO - 10.3949/ccjm.83a.14104 VL - 83 IS - 2 AU - Sumita B. Khatri AU - Octavian C. Ioachimescu Y1 - 2016/02/01 UR - http://www.ccjm.org/content/83/2/127.abstract N2 - Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) have synergistic detrimental effects. Their comorbid association leads to compromised gas exchange (hypoxia and hypercapnia) and higher rates of morbidity and death. As our understanding of the pathophysiologic processes of sleep evolves, the relation-ship between OSA and obstructive lung diseases such as COPD (“overlap syndrome”) or asthma (“alternative overlap syndrome”) has become more apparent. The pathophysiology of the combined conditions and optimal management are still being defined, but the effect on quality of life and morbidity underscore the importance of proper diagnosis and appropriately tailored management in these patients. ER -