PT - JOURNAL ARTICLE AU - Derek M. Tang AU - Nathalie H. Urrunaga AU - Erik C. Von Rosenvinge TI - Pseudomembranous colitis: Not always <em>Clostridium difficile</em> AID - 10.3949/ccjm.83a.14183 DP - 2016 May 01 TA - Cleveland Clinic Journal of Medicine PG - 361--366 VI - 83 IP - 5 4099 - http://www.ccjm.org/content/83/5/361.short 4100 - http://www.ccjm.org/content/83/5/361.full SO - Cleve Clin J Med2016 May 01; 83 AB - Although Clostridium difficile infection is the cause of most cases of pseudomembranous colitis, clinicians should consider less common causes, especially if pseudomembranes are seen on endoscopy but testing remains negative for C difficile or if presumed C difficile infection does not respond to treatment. Histologic review of colonic mucosal biopsy specimens can provide clues to the underlying cause.