RT Journal Article SR Electronic T1 Pseudomembranous colitis: Not always Clostridium difficile JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 361 OP 366 DO 10.3949/ccjm.83a.14183 VO 83 IS 5 A1 Tang, Derek M. A1 Urrunaga, Nathalie H. A1 Von Rosenvinge, Erik C. YR 2016 UL http://www.ccjm.org/content/83/5/361.abstract AB Although Clostridium difficile infection is the cause of most cases of pseudomembranous colitis, clinicians should consider less common causes, especially if pseudomembranes are seen on endoscopy but testing remains negative for C difficile or if presumed C difficile infection does not respond to treatment. Histologic review of colonic mucosal biopsy specimens can provide clues to the underlying cause.