RT Journal Article SR Electronic T1 The role of hemoglobin A1c in the assessment of diabetes and cardiovascular risk JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP S4 OP S10 DO 10.3949/ccjm.83.s1.02 VO 83 IS 5 suppl 1 A1 Sandler, Courtney Nagel A1 McDonnell, Marie E. YR 2016 UL http://www.ccjm.org/content/83/5_suppl_1/S4.abstract AB Hemoglobin A1c (HbA1c) is a widely used tool for diagnosing, screening, and managing patients with diabetes; however, proper application and interpretation of the HbA1c test is crucial to master for accurate assessment of patients. It also has become the standard test in population-based studies for evaluating the relationship between glycemic control and cardiovascular risk. Result from large clinical trials support the modern perspective that the HbA1c target should be personalized according to the risks and benefits of glycemic control. This likely is most important in patients with diabetes and elevated cardiovascular risk in whom achieving low HbA1c levels early in the natural history may be the most beneficial.