RT Journal Article SR Electronic T1 Total pancreatectomy and islet cell autotransplantation: Definitive treatment for chronic pancreatitis JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 435 OP 442 DO 10.3949/ccjm.83a.15056 VO 83 IS 6 A1 Karla M. Arce A1 Yu Kuei Lin A1 Tyler Stevens A1 R. Matthew Walsh A1 Betul A. Hatipoglu YR 2016 UL http://www.ccjm.org/content/83/6/435.abstract AB In appropriately selected patients, total pancreatectomy and islet cell autotransplant controls pain and improves quality of life while often minimizing the development of overt diabetes. Multidisciplinary management and lifelong follow-up help to maximize the benefit of this procedure. This review highlights its history, indications, metabolic outcomes, and future directions.