RT Journal Article SR Electronic T1 A guide to managing acute liver failure JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 453 OP 462 DO 10.3949/ccjm.83a.15101 VO 83 IS 6 A1 Singh, Tavankit A1 Gupta, Nancy A1 Alkhouri, Naim A1 Carey, William D. A1 Hanouneh, Ibrahim A. YR 2016 UL http://www.ccjm.org/content/83/6/453.abstract AB Nearly 2,000 cases of acute liver failure occur each year in the United States. This disease carries a high mortality rate, and early recognition and transfer to a tertiary medical care center with transplant facilities is critical. This article reviews the definition, epidemiology, etiology, and management of acute liver failure.