RT Journal Article SR Electronic T1 Dronedarone for atrial fibrillation: How does it compare with amiodarone? JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 179 OP 185 DO 10.3949/ccjm.78a.10049 VO 78 IS 3 A1 Penugonda, Neelima A1 Mohmand-Borkowski, Adam A1 Burke, James F. YR 2011 UL http://www.ccjm.org/content/78/3/179.abstract AB Dronedarone (Multaq), an analogue of amiodarone (Cordarone), was designed to cause fewer adverse effects than the parent compound. Studies have indeed shown dronedarone to be safer than amiodarone, but less effective. Its official indication is to reduce the risk of hospitalization in patients with paroxysmal or persistent atrial fibrillation or atrial flutter and other cardiovascular risk factors, reflecting the parameters of its effectiveness in clinical trials.