PT - JOURNAL ARTICLE AU - Amy Schilling AU - Elizabeth Neuner AU - Susan J. Rehm TI - Vancomycin: A 50-something-yearold antibiotic we still don’t understand AID - 10.3949/ccjm.78a.10168 DP - 2011 Jul 01 TA - Cleveland Clinic Journal of Medicine PG - 465--471 VI - 78 IP - 7 4099 - http://www.ccjm.org/content/78/7/465.short 4100 - http://www.ccjm.org/content/78/7/465.full SO - Cleve Clin J Med2011 Jul 01; 78 AB - Because a significant proportion of Staphylococcus aureus strains as well as most coagulase-negative staphylococci are resistant to penicillin and semisynthetic beta-lactam drugs, the need for vancomycin and related antibiotics has never been greater. Effective use of vancomycin requires knowledge of dosing parameters and selection of target trough levels appropriate to the specific infection and to the pathogen being treated. For clinicians, it is vital to remain up-to-date with evolving definitions for vancomycin susceptibility, with new interpretations of efficacy, and with information on toxicity.