RT Journal Article
SR Electronic
T1 Vancomycin: A 50-something-yearold antibiotic we still don’t understand
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 465
OP 471
DO 10.3949/ccjm.78a.10168
VO 78
IS 7
A1 Amy Schilling
A1 Elizabeth Neuner
A1 Susan J. Rehm
YR 2011
UL http://www.ccjm.org/content/78/7/465.abstract
AB Because a significant proportion of Staphylococcus aureus strains as well as most coagulase-negative staphylococci are resistant to penicillin and semisynthetic beta-lactam drugs, the need for vancomycin and related antibiotics has never been greater. Effective use of vancomycin requires knowledge of dosing parameters and selection of target trough levels appropriate to the specific infection and to the pathogen being treated. For clinicians, it is vital to remain up-to-date with evolving definitions for vancomycin susceptibility, with new interpretations of efficacy, and with information on toxicity.