TY - JOUR T1 - Vancomycin: A 50-something-yearold antibiotic we still don’t understand JF - Cleveland Clinic Journal of Medicine JO - Cleve Clin J Med SP - 465 LP - 471 DO - 10.3949/ccjm.78a.10168 VL - 78 IS - 7 AU - Amy Schilling AU - Elizabeth Neuner AU - Susan J. Rehm Y1 - 2011/07/01 UR - http://www.ccjm.org/content/78/7/465.abstract N2 - Because a significant proportion of Staphylococcus aureus strains as well as most coagulase-negative staphylococci are resistant to penicillin and semisynthetic beta-lactam drugs, the need for vancomycin and related antibiotics has never been greater. Effective use of vancomycin requires knowledge of dosing parameters and selection of target trough levels appropriate to the specific infection and to the pathogen being treated. For clinicians, it is vital to remain up-to-date with evolving definitions for vancomycin susceptibility, with new interpretations of efficacy, and with information on toxicity. ER -