PT  - JOURNAL ARTICLE
AU  - Heesun J. Rogers
AU  - Charles Allen
AU  - Alan E. Lichtin
TI  - Thrombotic thrombocytopenic purpura: The role of ADAMTS13
AID  - 10.3949/ccjm.83a.15009
DP  - 2016 Aug 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 597--603
VI  - 83
IP  - 8
4099  - http://www.ccjm.org/content/83/8/597.short
4100  - http://www.ccjm.org/content/83/8/597.full
SO  - Cleve Clin J Med2016 Aug 01; 83
AB  - Thrombotic thrombocytopenic purpura (TTP) is an uncommon, life-threatening disease requiring prompt diagnosis and initiation of therapeutic plasma exchange to improve patient survival. However, diagnosis is often difficult because of atypical presentations and signs and symptoms that resemble other conditions. Measurements of ADAMTS13 activity, ADAMTS13 inhibitor, and ADAMTS13 autoantibody are useful for diagnosing TTP, guiding therapy, and predicting relapse.