RT Journal Article
SR Electronic
T1 Thrombotic thrombocytopenic purpura: The role of ADAMTS13
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 597
OP 603
DO 10.3949/ccjm.83a.15009
VO 83
IS 8
A1 Heesun J. Rogers
A1 Charles Allen
A1 Alan E. Lichtin
YR 2016
UL http://www.ccjm.org/content/83/8/597.abstract
AB Thrombotic thrombocytopenic purpura (TTP) is an uncommon, life-threatening disease requiring prompt diagnosis and initiation of therapeutic plasma exchange to improve patient survival. However, diagnosis is often difficult because of atypical presentations and signs and symptoms that resemble other conditions. Measurements of ADAMTS13 activity, ADAMTS13 inhibitor, and ADAMTS13 autoantibody are useful for diagnosing TTP, guiding therapy, and predicting relapse.