PT - JOURNAL ARTICLE AU - David C. Peritz AU - Eugene H. Chung TI - Left atrial appendage closure: An emerging option in atrial fibrillation when oral anticoagulants are not tolerated AID - 10.3949/ccjm.82a.14117 DP - 2015 Mar 01 TA - Cleveland Clinic Journal of Medicine PG - 167--176 VI - 82 IP - 3 4099 - http://www.ccjm.org/content/82/3/167.short 4100 - http://www.ccjm.org/content/82/3/167.full SO - Cleve Clin J Med2015 Mar 01; 82 AB - Atrial fibrillation is associated with a risk of stroke, primarily from embolization of clots that form in the left atrial appendage. This structure has been targeted to reduce stroke risk in patients who have contraindications to oral anticoagulation. This article appraises the current literature describing surgical and percutaneous isolation of the left atrial appendage.