RT Journal Article SR Electronic T1 Left atrial appendage closure: An emerging option in atrial fibrillation when oral anticoagulants are not tolerated JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 167 OP 176 DO 10.3949/ccjm.82a.14117 VO 82 IS 3 A1 David C. Peritz A1 Eugene H. Chung YR 2015 UL http://www.ccjm.org/content/82/3/167.abstract AB Atrial fibrillation is associated with a risk of stroke, primarily from embolization of clots that form in the left atrial appendage. This structure has been targeted to reduce stroke risk in patients who have contraindications to oral anticoagulation. This article appraises the current literature describing surgical and percutaneous isolation of the left atrial appendage.