PT  - JOURNAL ARTICLE
AU  - Anthony P. Fernandez
TI  - Dermatology update: The dawn of targeted treatment
AID  - 10.3949/ccjm.82gr.15002
DP  - 2015 May 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 309--320
VI  - 82
IP  - 5
4099  - http://www.ccjm.org/content/82/5/309.short
4100  - http://www.ccjm.org/content/82/5/309.full
SO  - Cleve Clin J Med2015 May 01; 82
AB  - During the past several years, targeted therapies have significantly improved outcomes in advanced basal cell carcinoma, psoriasis, and metastatic melanoma. This article reviews how advances in our understanding of the molecular pathogenesis of these diseases led to the development of targeted therapies and how these therapies are improving outcomes. Research is ongoing to address continuing challenges of drug resistance, adverse effects, and how best to use the new medications.