PT  - JOURNAL ARTICLE
AU  - Alexei Gonzalez-Estrada
AU  - Cristine Radojicic
TI  - Penicillin allergy: A practical guide for clinicians
AID  - 10.3949/ccjm.82a.14111
DP  - 2015 May 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 295--300
VI  - 82
IP  - 5
4099  - http://www.ccjm.org/content/82/5/295.short
4100  - http://www.ccjm.org/content/82/5/295.full
SO  - Cleve Clin J Med2015 May 01; 82
AB  - Penicillin allergy is the most commonly reported drug allergy in the United States. However, after undergoing a complete evaluation by a board-certified allergist, including skin testing, 90% of patients labeled as “penicillin-allergic” are able to tolerate penicillin. Clinical presentation is key in classifying reactions as either mediated by or not mediated by immunoglobulin E (IgE), and in determining which patients may benefit from penicillin skin testing, graded-dose challenge, or desensitization. Cross-reactivity between penicillin and other beta-lactams is less common than previously thought.