TY - JOUR T1 - Penicillin allergy: A practical guide for clinicians JF - Cleveland Clinic Journal of Medicine JO - Cleve Clin J Med SP - 295 LP - 300 DO - 10.3949/ccjm.82a.14111 VL - 82 IS - 5 AU - Alexei Gonzalez-Estrada AU - Cristine Radojicic Y1 - 2015/05/01 UR - http://www.ccjm.org/content/82/5/295.abstract N2 - Penicillin allergy is the most commonly reported drug allergy in the United States. However, after undergoing a complete evaluation by a board-certified allergist, including skin testing, 90% of patients labeled as “penicillin-allergic” are able to tolerate penicillin. Clinical presentation is key in classifying reactions as either mediated by or not mediated by immunoglobulin E (IgE), and in determining which patients may benefit from penicillin skin testing, graded-dose challenge, or desensitization. Cross-reactivity between penicillin and other beta-lactams is less common than previously thought. ER -