RT Journal Article
SR Electronic
T1 Penicillin allergy: A practical guide for clinicians
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 295
OP 300
DO 10.3949/ccjm.82a.14111
VO 82
IS 5
A1 Alexei Gonzalez-Estrada
A1 Cristine Radojicic
YR 2015
UL http://www.ccjm.org/content/82/5/295.abstract
AB Penicillin allergy is the most commonly reported drug allergy in the United States. However, after undergoing a complete evaluation by a board-certified allergist, including skin testing, 90% of patients labeled as “penicillin-allergic” are able to tolerate penicillin. Clinical presentation is key in classifying reactions as either mediated by or not mediated by immunoglobulin E (IgE), and in determining which patients may benefit from penicillin skin testing, graded-dose challenge, or desensitization. Cross-reactivity between penicillin and other beta-lactams is less common than previously thought.