PT - JOURNAL ARTICLE AU - Lu, Marvin Louis Roy Y. AU - Agito, Markus D. TI - Marijuana is both antiemetic and proemetic AID - 10.3949/ccjm.82a.14023 DP - 2015 Jul 01 TA - Cleveland Clinic Journal of Medicine PG - 429--434 VI - 82 IP - 7 4099 - http://www.ccjm.org/content/82/7/429.short 4100 - http://www.ccjm.org/content/82/7/429.full SO - Cleve Clin J Med2015 Jul 01; 82 AB - Although marijuana is sometimes used to treat chemotherapy-induced nausea and vomiting, when used long-term it can have a paradoxical hyperemetic effect known as cannabinoid hyperemesis syndrome. Knowledge of this phenomenon may reduce the ordering of unnecessary and expensive investigations, as well as inappropriate medical and surgical treatment in patients presenting with recurrent vomiting of unknown cause. This article reviews the pathophysiology, clinical presentation, diagnosis, and management of this emerging condition.