RT Journal Article SR Electronic T1 Marijuana is both antiemetic and proemetic JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 429 OP 434 DO 10.3949/ccjm.82a.14023 VO 82 IS 7 A1 Lu, Marvin Louis Roy Y. A1 Agito, Markus D. YR 2015 UL http://www.ccjm.org/content/82/7/429.abstract AB Although marijuana is sometimes used to treat chemotherapy-induced nausea and vomiting, when used long-term it can have a paradoxical hyperemetic effect known as cannabinoid hyperemesis syndrome. Knowledge of this phenomenon may reduce the ordering of unnecessary and expensive investigations, as well as inappropriate medical and surgical treatment in patients presenting with recurrent vomiting of unknown cause. This article reviews the pathophysiology, clinical presentation, diagnosis, and management of this emerging condition.