RT Journal Article SR Electronic T1 Urologic applications of botulinum toxin JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 456 OP 464 DO 10.3949/ccjm.82a.13166 VO 82 IS 7 A1 King, Ashley A1 Quirouet, Adrienne A1 Moore, Courtenay K. YR 2015 UL http://www.ccjm.org/content/82/7/456.abstract AB The neuromuscular blocker botulinum toxin has a wide variety of medical applications, including overactive bladder and neurogenic detrusor overactivity in patients in whom drug therapy fails or is not well tolerated. Botulinum toxin therapy for these conditions has been shown to be safe and effective in several large multicenter randomized controlled trials. Off-label uses in urology include detrusor external sphincter dyssynergia and pelvic pain syndromes.