RT Journal Article SR Electronic T1 Genitourinary manifestations of sickle cell disease JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 679 OP 683 DO 10.3949/ccjm.82a.14029 VO 82 IS 10 A1 Surafel Gebreselassie A1 Matthew N. Simmons A1 Drogo K. Montague YR 2015 UL http://www.ccjm.org/content/82/10/679.abstract AB Sickle cell disease is a common genetic disorder characterized by sickling of red blood cells under conditions of reduced oxygen tension. In turn, sickling leads to intravascular hemolysis and vaso-occlusive events with subsequent tissue ischemia-reperfusion injury affecting multiple organs, including the genitourinary system. Our review of the genitourinary manifestations of sickle cell disease focuses on sickle cell nephropathy, priapism, and other genitourinary complications such as papillary necrosis and renal medullary carcinoma.