RT Journal Article
SR Electronic
T1 Evolving strategies to prevent stroke and thromboembolism in nonvalvular atrial fibrillation
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP S11
OP S16
DO 10.3949/ccjm.82.s2.03
VO 82
IS 12 suppl 2
A1 Ayman Hussein
A1 Walid Saliba
A1 Oussama Wazni
YR 2015
UL http://www.ccjm.org/content/82/12_suppl_2/S11.abstract
AB Stroke prevention in patients with nonvalvular atrial fibrillation relies on an assessment of the individual risks for stroke and bleeding. Patients at high risk for stroke are candidates for anticoagulant therapy. Anticoagulants, however, have substantial bleeding risks that must be weighed in the therapeutic decision. Warfarin has been the traditional choice, but the recently introduced novel oral anticoagulants offer similar efficacy with less bleeding risk. Additionally, they do not require monitoring and have fewer drug interactions and dietary restrictions than warfarin. Several devices, which isolate the left atrial appendage, have become available as treatment options for patients with elevated risks of both thromboembolism and bleeding complications.