PT - JOURNAL ARTICLE AU - Mehdi H. Shishehbor TI - Acute and critical limb ischemia: When time is limb AID - 10.3949/ccjm.81gr.13003 DP - 2014 Apr 01 TA - Cleveland Clinic Journal of Medicine PG - 209--216 VI - 81 IP - 4 4099 - http://www.ccjm.org/content/81/4/209.short 4100 - http://www.ccjm.org/content/81/4/209.full SO - Cleve Clin J Med2014 Apr 01; 81 AB - Acute and critical limb ischemia post significant rates of morbidity and death, and need to be promptly recognized and treated to avoid amputation. Perfusion should be thoroughly assessed using multiple methods, and patients should be considered for revascularization (angioplasty or bypass surgery) to restore blood perfusion. Underlying conditions that need to be assessed and treated include cardiovascular disease, diabetes, and infection.