RT Journal Article SR Electronic T1 Acute and critical limb ischemia: When time is limb JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 209 OP 216 DO 10.3949/ccjm.81gr.13003 VO 81 IS 4 A1 Mehdi H. Shishehbor YR 2014 UL http://www.ccjm.org/content/81/4/209.abstract AB Acute and critical limb ischemia post significant rates of morbidity and death, and need to be promptly recognized and treated to avoid amputation. Perfusion should be thoroughly assessed using multiple methods, and patients should be considered for revascularization (angioplasty or bypass surgery) to restore blood perfusion. Underlying conditions that need to be assessed and treated include cardiovascular disease, diabetes, and infection.