PT - JOURNAL ARTICLE AU - Venu Menon AU - Bhuvnesh Aggarwal TI - Why are we doing cardiovascular outcome trials in type 2 diabetes? AID - 10.3949/ccjm.81gr.14005 DP - 2014 Nov 01 TA - Cleveland Clinic Journal of Medicine PG - 665--671 VI - 81 IP - 11 4099 - http://www.ccjm.org/content/81/11/665.short 4100 - http://www.ccjm.org/content/81/11/665.full SO - Cleve Clin J Med2014 Nov 01; 81 AB - Cardiovascular disease is the leading cause of morbidity and death in people with diabetes mellitus. While worsening hyperglycemia is directly associated with poorer outcomes, studies aiming at euglycemia have failed to show an advantage over modest glucose-lowering strategies. Several diabetes drugs that were approved solely on the basis of their glucose-lowering potential were later shown to increase cardiovascular risk.