RT Journal Article
SR Electronic
T1 Why are we doing cardiovascular outcome trials in type 2 diabetes?
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 665
OP 671
DO 10.3949/ccjm.81gr.14005
VO 81
IS 11
A1 Venu Menon
A1 Bhuvnesh Aggarwal
YR 2014
UL http://www.ccjm.org/content/81/11/665.abstract
AB Cardiovascular disease is the leading cause of morbidity and death in people with diabetes mellitus. While worsening hyperglycemia is directly associated with poorer outcomes, studies aiming at euglycemia have failed to show an advantage over modest glucose-lowering strategies. Several diabetes drugs that were approved solely on the basis of their glucose-lowering potential were later shown to increase cardiovascular risk.