PT  - JOURNAL ARTICLE
AU  - Jemima Albayda
AU  - Lisa Christopher-Stine
TI  - Identifying statin-associated autoimmune necrotizing myopathy
AID  - 10.3949/ccjm.81a.13158
DP  - 2014 Dec 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 736--741
VI  - 81
IP  - 12
4099  - http://www.ccjm.org/content/81/12/736.short
4100  - http://www.ccjm.org/content/81/12/736.full
SO  - Cleve Clin J Med2014 Dec 01; 81
AB  - Statins up-regulate expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), the rate-limiting enzyme in cholesterol synthesis and the major target of autoantibodies in statin-associated immune-mediated necrotizing myopathy. As muscle cells regenerate, they express high levels of HMGCR, which may sustain the immune response even after statin therapy is stopped. Awareness of this entity will help physicians who prescribe statins to take action to limit the associated morbidity.