RT Journal Article SR Electronic T1 Identifying statin-associated autoimmune necrotizing myopathy JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 736 OP 741 DO 10.3949/ccjm.81a.13158 VO 81 IS 12 A1 Jemima Albayda A1 Lisa Christopher-Stine YR 2014 UL http://www.ccjm.org/content/81/12/736.abstract AB Statins up-regulate expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), the rate-limiting enzyme in cholesterol synthesis and the major target of autoantibodies in statin-associated immune-mediated necrotizing myopathy. As muscle cells regenerate, they express high levels of HMGCR, which may sustain the immune response even after statin therapy is stopped. Awareness of this entity will help physicians who prescribe statins to take action to limit the associated morbidity.