TY - JOUR T1 - Identifying statin-associated autoimmune necrotizing myopathy JF - Cleveland Clinic Journal of Medicine JO - Cleve Clin J Med SP - 736 LP - 741 DO - 10.3949/ccjm.81a.13158 VL - 81 IS - 12 AU - Jemima Albayda AU - Lisa Christopher-Stine Y1 - 2014/12/01 UR - http://www.ccjm.org/content/81/12/736.abstract N2 - Statins up-regulate expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), the rate-limiting enzyme in cholesterol synthesis and the major target of autoantibodies in statin-associated immune-mediated necrotizing myopathy. As muscle cells regenerate, they express high levels of HMGCR, which may sustain the immune response even after statin therapy is stopped. Awareness of this entity will help physicians who prescribe statins to take action to limit the associated morbidity. ER -