PT  - JOURNAL ARTICLE
AU  - Daniel S. Socha
AU  - Sherwin I. DeSouza
AU  - Aron Flagg
AU  - Mikkael Sekeres
AU  - Heesun J. Rogers
TI  - Severe megaloblastic anemia: Vitamin deficiency and other causes
AID  - 10.3949/ccjm.87a.19072
DP  - 2020 Mar 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 153--164
VI  - 87
IP  - 3
4099  - http://www.ccjm.org/content/87/3/153.short
4100  - http://www.ccjm.org/content/87/3/153.full
SO  - Cleve Clin J Med2020 Mar 01; 87
AB  - Megaloblastic anemia causes macrocytic anemia from ineffective red blood cell production and intramedullary hemolysis. The most common causes are folate (vitamin B9) deficiency and cobalamin (vitamin B12) deficiency. Megaloblastic anemia can be diagnosed based on characteristic morphologic and laboratory findings. However, other benign and neoplastic diseases need to be considered, particularly in severe cases. Therapy involves treating the underlying cause—eg, with vitamin supplementation in cases of deficiency, or with discontinuation of a suspected medication.