TY - JOUR T1 - Severe megaloblastic anemia: Vitamin deficiency and other causes JF - Cleveland Clinic Journal of Medicine JO - Cleve Clin J Med SP - 153 LP - 164 DO - 10.3949/ccjm.87a.19072 VL - 87 IS - 3 AU - Daniel S. Socha AU - Sherwin I. DeSouza AU - Aron Flagg AU - Mikkael Sekeres AU - Heesun J. Rogers Y1 - 2020/03/01 UR - http://www.ccjm.org/content/87/3/153.abstract N2 - Megaloblastic anemia causes macrocytic anemia from ineffective red blood cell production and intramedullary hemolysis. The most common causes are folate (vitamin B9) deficiency and cobalamin (vitamin B12) deficiency. Megaloblastic anemia can be diagnosed based on characteristic morphologic and laboratory findings. However, other benign and neoplastic diseases need to be considered, particularly in severe cases. Therapy involves treating the underlying causeā€”eg, with vitamin supplementation in cases of deficiency, or with discontinuation of a suspected medication. ER -