RT Journal Article
SR Electronic
T1 The role of adjuvant chemotherapy in early-stage and locally advanced non–small cell lung cancer
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP S42
OP S45
DO 10.3949/ccjm.79.s2.09
VO 79
IS 5 e-suppl 1
A1 Shapiro, Marc
YR 2012
UL http://www.ccjm.org/content/79/5_e-suppl_1/S42.abstract
AB Adjuvant chemotherapy benefits only a small proportion of patients in the setting of resected early-stage non– small cell lung cancer, and in unselected patients, any benefit is modest. Analysis of clinical trials of adjuvant chemotherapy revealed that differential expression of DNA repair proteins and a 15-gene expression profile affected outcomes with treatment. Biomarkers and gene expression profiles are now being studied in prospective clinical trials to gauge their value in selection of adjuvant therapy and individualization of therapy.