RT Journal Article SR Electronic T1 Psoriasis: Evolving treatment for a complex disease JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 413 OP 423 DO 10.3949/ccjm.79a.11133 VO 79 IS 6 A1 VillaseƱor-Park, Jennifer A1 Wheeler, David A1 Grandinetti, Lisa YR 2012 UL http://www.ccjm.org/content/79/6/413.abstract AB The cutaneous manifestations of psoriasis can vary in morphology and severity, and therapy should be tailored accordingly. Biologic agents are important new options for treating patients with the most severe forms of the disease. All physicians should be aware that severe psoriasis may increase cardiovascular morbidity and the risk of death, and preventive strategies for patients with severe disease should be considered.