PT - JOURNAL ARTICLE AU - Thomas, George AU - Shishehbor, Mehdi H. AU - Bravo, Emmanuel L. AU - Nally, Joseph V. TI - Renal denervation to treat resistant hypertension: Guarded optimism AID - 10.3949/ccjm.79a.12040 DP - 2012 Jul 01 TA - Cleveland Clinic Journal of Medicine PG - 501--510 VI - 79 IP - 7 4099 - http://www.ccjm.org/content/79/7/501.short 4100 - http://www.ccjm.org/content/79/7/501.full SO - Cleve Clin J Med2012 Jul 01; 79 AB - Renal sympathetic denervation has shown promise in treating hypertension resistant to drug therapy. This procedure lowers blood pressure via targeted attenuation of renal sympathetic tone, and it has a favorable safety profile. But although there is reason for cautious optimism, we should keep in mind that the mechanisms of hypertension are complex and multifactorial, and further study of this novel therapy and its long-term effects is needed.