RT Journal Article SR Electronic T1 Renal denervation to treat resistant hypertension: Guarded optimism JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 501 OP 510 DO 10.3949/ccjm.79a.12040 VO 79 IS 7 A1 Thomas, George A1 Shishehbor, Mehdi H. A1 Bravo, Emmanuel L. A1 Nally, Joseph V. YR 2012 UL http://www.ccjm.org/content/79/7/501.abstract AB Renal sympathetic denervation has shown promise in treating hypertension resistant to drug therapy. This procedure lowers blood pressure via targeted attenuation of renal sympathetic tone, and it has a favorable safety profile. But although there is reason for cautious optimism, we should keep in mind that the mechanisms of hypertension are complex and multifactorial, and further study of this novel therapy and its long-term effects is needed.