PT  - JOURNAL ARTICLE
AU  - Swapna Thota
AU  - Gaurav Kistangari
AU  - Hamed Daw
AU  - Timothy Spiro
TI  - Immune thrombocytopenia in adults: An update
AID  - 10.3949/ccjm.79a.11027
DP  - 2012 Sep 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 641--650
VI  - 79
IP  - 9
4099  - http://www.ccjm.org/content/79/9/641.short
4100  - http://www.ccjm.org/content/79/9/641.full
SO  - Cleve Clin J Med2012 Sep 01; 79
AB  - Immune thrombocytopenia (ITP) in adults is a chronic disease resulting from increased platelet destruction and impaired platelet production. Splenectomy remains the most effective and durable treatment in cases that are refractory to first-line therapy, but its use has declined because of the availability of alternate medical therapy, the associated risk of infection, and concern for surgeryrelated complications. Rituximab (Rituxan) may be an effective alternative but carries the risk of immunosuppression.