RT Journal Article
SR Electronic
T1 Immune thrombocytopenia in adults: An update
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 641
OP 650
DO 10.3949/ccjm.79a.11027
VO 79
IS 9
A1 Swapna Thota
A1 Gaurav Kistangari
A1 Hamed Daw
A1 Timothy Spiro
YR 2012
UL http://www.ccjm.org/content/79/9/641.abstract
AB Immune thrombocytopenia (ITP) in adults is a chronic disease resulting from increased platelet destruction and impaired platelet production. Splenectomy remains the most effective and durable treatment in cases that are refractory to first-line therapy, but its use has declined because of the availability of alternate medical therapy, the associated risk of infection, and concern for surgeryrelated complications. Rituximab (Rituxan) may be an effective alternative but carries the risk of immunosuppression.