PT  - JOURNAL ARTICLE
AU  - Jayne, David
TI  - Treating vasculitis with conventional immunosuppressive agents
AID  - 10.3949/ccjm.79.s3.10
DP  - 2012 Nov 01
TA  - Cleveland Clinic Journal of Medicine
PG  - S46--S49
VI  - 79
IP  - 11 suppl 3
4099  - http://www.ccjm.org/content/79/11_suppl_3/S46.short
4100  - http://www.ccjm.org/content/79/11_suppl_3/S46.full
SO  - Cleve Clin J Med2012 Nov 01; 79
AB  - Standard therapy for granulomatosis with polyangiitis and other vasculitides is a combination of cyclophosphamide and glucocorticoids. Although most patients achieve remission, relapses and treatment-related morbidities are common. Clinical trials have yielded a wealth of data about less toxic alternatives to standard therapy, including new agents and methods of delivery. All aim to reduce long-term exposure to cyclophosphamide and glucocorticoids and so maintain safety while effectively preventing relapse. Individualized evaluation of risk and treatment selection will help maximize effectiveness and minimize toxicity.